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11 : Everyday Life And The Progenitor

As it gets dark, Hiraku's work day is over and he heads inside for dinner. The maids present him with a new dish, stating they are confident about it good taste about 20%. Hiraku tells them to only present dishes where they are at least 50% confident its good. However, the maid refuses as they don't want to waste food. Fraurem gives Hiraku a letter from Yuuri in which he reads that she wants to eat apples again and a dress. Fraurem then explains that Yuuri liked the clothes that Zabuton made and is wondering if Zabuton can make more for her. After resting a bit after dinner, Hiraku takes a bath and is usually the only one there (but in reality he was in women's bath temporarily). After the bath, Hiraku usually feels unease as the elves start stalking him. Even in his room, he still feels they watch him and tricks them into revealing themselves. After that, he thanks God again for the good life he was given and falls asleep.

11 : Everyday Life and the Progenitor

The dwarves are usually always working making alcohol. Hiraku expected they to be always drunk, but they take their job quite seriously and don't drink while working. They also ask him to increase the grape production by three times and Hiraku agrees. Sena comes running and informs Hiraku that there is a strange man. Hiraku goes to check him and sees the man bowing to the wooden god statues Hiraku had made. Hiraku then wonders how he got in without Zabuton or the angels seeing him. Ru recognizes that he is the Progenitor, Vargryfe, who is quite happy to see her. Vargryfe explains that when he heard she is pregnant, he didn't believe it, but it seems its true. Normally they continue their bloodline with bloodpacts and pregnancies are rare, but states that children are treasure and tells her to take care of it. Hiraku wonders who is he and Ru states he can think of him as he grandfather. Vargryfe explains that he is 4000 years old and the secret in living a long life is to erase his memory from time to time, except the important things like his name and clan. Vargryfe apologizes for entering the village without notification, and explains that he initially only intended to look around and leave, but the statue below the tree caught his attention, as it was splendid likeness of the great creator. Hiraku wonders if he met God before and Vargryfe confirms that he met him when he was born and God told him that do his best even though he is born with a slightly abnormal body. Hiraku figures the abnormal body means that he is vampire and Vargryfe guesses so too. Vargryfe explains that he have been trying to remember how exactly God looked and it must be great to live to such statue. Hiraku realizes that he wants the statue and explains that he can't give it to him since it belongs to the village, but he will make him a new one. After making him a statue, Vargryfe likes it. He wonders how much it would cost him, but Hiraku doesn't want to take money for something like that. Vargryfe then states he will have to think what he can do for him as thanks.

After leaving the village, Vargryfe visits a large temple. The head priest there is happy to see him noting it was 50 years since he last visited. Vargryfe states he wants to enshrine a statue and asks what is the best spot. The priest explains it is the spot of the creator god statue which was made by the master sculptor Toorook. Vargryfe then wants to move it in order to put the new statue there and the priest agrees. Seeing the statue, the priest is impressed stating it must have been made by a famous sculptor and wonders about his name so they can honor it, but Vargryfe it would be better if they don't do that as Hiraku doesn't seem the type to appreciate stuff like that and also doesn't want to disturb his peaceful life. Vargryfe states they quietly support him and tells the priest to inform the other temples and they all to be respectful of the Taiju Village.

Vargryfe send Hiraku a magnificent piano. Hiraku doesn't want to take it as payment, but Vargryfe then states its gift to celebrate Ru's pregnancy. Hiraku decides to put the piano in the dinning hall. The Three Hall girls realize that its a piano that can only be found in the large temples and is used for big ceremonies. They decide to play it as its one of a lifetime opportunity. However, they end up too scared to play on it as they fear they may ruin it or break it. The three of them then ask Hiraku if he can get them a piano so they can practice on it. Hiraku doesn't understand why they don't want to play on the current one, but makes Michael Goroun get him a practice piano. A lot of the girls end up enjoying the piano and try learning to play on it. However, Hiraku have trouble sleeping as they also play on it at night.

The materials gathered for Experiments in the Everyday have rarely been seen by the American public and have never before been assembled in a direct critical dialog. The exhibition brings into focus the important contributions that Kaprow and Watts have made in the reshaping of advanced art-making practices in the second half of the twentieth century. Both artists were engaged with process, intermedia, game-based composition, interactivity, and an increasingly technological everyday life. Allan Kaprow (b. 1927) is perhaps best known as the progenitor of collage-like collaborative performances known as Happenings, which moved art out of the rarefied confines of museums and galleries and into everyday spaces. Robert Watts (1923-1988), key figure in the quasi-anarchic artists' collective known as Fluxus, was equally interested in breaking down the distinctions between art and the everyday, producing unconventional objects and projects that are both playful and provocative.

In healthy individuals, skin integrity is maintained by epidermal stem cells which self-renew and generate daughter cells that undergo terminal differentiation. Despite accumulation of senescence markers in aged skin, epidermal stem cells are maintained at normal levels throughout life. Therefore, skin ageing is induced by impaired stem cell mobilisation or reduced number of stem cells able to respond to proliferative signals. In the skin, existence of several distinct stem cell populations has been reported. Genetic labelling studies detected multipotent stem cells of the hair follicle bulge to support regeneration of hair follicles but not been responsible for maintaining interfollicular epidermis, which exhibits a distinct stem cell population. Hair follicle epithelial stem cells have at least a dual function: hair follicle remodelling in daily life and epidermal regeneration whenever skin integrity is severely compromised, e.g. after burns. Bulge cells, the first adult stem cells of the hair follicle been identified, are capable of forming hair follicles, interfollicular epidermis and sebaceous glands. In addition, -- at least in murine hair follicles -- they can also give rise to non-epithelial cells, indicating a lineage-independent pluripotent character. Multipotent cells (skin-derived precursor cells) are present in human dermis; dermal stem cells represent 0.3% among human dermal foreskin fibroblasts. A resident pool of progenitor cells exists within the sebaceous gland, which is able to differentiate into both sebocytes and interfollicular epidermis. The self-renewal and multi-lineage differentiation of skin stem cells make these cells attractive for ageing process studies but also for regenerative medicine, tissue repair, gene therapy and cell-based therapy with autologous adult stem cells not only in dermatology. In addition, they provide in vitro models to study epidermal lineage selection and its role in the ageing process.

In one study (abstract 3797), researchers investigated whether exercise training could activate progenitor cells, a pool of immature cells in skeletal muscle that can divide into various mature cells as needed for muscle repair.

"With exercise, the number of progenitor cells became almost normal, the cells started to divide again, and they began to differentiate into myocytes (muscle cells). And that's exactly what patients with heart failure need -- replacement of muscle cells," Linke said.

In the second study (abstract 3796), researchers tracked endothelial progenitor cells that are created in bone marrow and circulate through the bloodstream. The cells help repair damaged blood vessel linings and spur new vessels to form in a process called vasculogenesis.

After Hiraku dies of a serious illness, God brings him back to life, gives his health and youth back, and sends him to a fantasy world of his choice. In order to enjoy his second shot, God bestows upon him the almighty farming tool! Watch as Hiraku digs, chops, and ploughs in another world in this laidback farming fantasy!

It is perhaps difficult for art lovers today to realize just how extraordinary a step Bosch, Massys, and Lucas van Leyden were taking. Nowadays the autonomy of art can be considered its defining feature, but five hundred years ago it was almost inconceivable that painting should depict anything but religious stories and portraits. The step that the three took was consequently a cautious one. Only a small proportion of their works deal with everyday life, by far the majority are tales from the Bible and the lives of the saints. The link between church and art was so much a matter of course that it was to take several generations before everyday scenes ceased to be the exception and became a generally recognized and accepted subject. This exhibition explores the first cohort of painters and printmakers who developed the new genre between, roughly, 1500 and 1570. This was a timespan bracketed by two of the most exceptional artists the Low Countries have ever produced: Hieronymus Bosch at the beginning and Pieter Bruegel the Elder at the end. But alongside them was a whole host of well-known and less familiar artists, such as Jan Sanders van Hemessen, Marinus van Reymerswale, the Brunswick Monogrammist, Jan Vermeyen, Pieter Aertsen, Joachim Beuckelaer, Peeter van der Borcht, and, of course, Quinten Massys and Lucas van Leyden, who first gave shape to the depiction of everyday reality and ensured that it would ever after be an indispensable part of visual art.4 041b061a72

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